Custom RNA Oligos
Whatever RNA you need—ssRNA, shRNA, aptamers, chimeric, or siRNA—we produce any kind of synthetic RNA for you.
- Custom ssRNA Oligos
Single-strand RNA up to 80 bases
Desalted or HPLC-purified
Synthesis scales from 0.05 to 1.0 µmol - O-Methyl-RNA / Chimerics
Mixed DNA/RNA bases, O-Methly-RNA, and PTO bounds
Sequence length from 6 – 80 bases
HPLC purified
Synthesis scales from 0.05 to 1.0 µmol - siMAX siRNA
Sequence lengths range from 17 – 27 bases
Annealed duplex, ready to use
HPLC purified - RNA Modifications
Fluorescent dyes
Non-fluorescent modifications
Spacer, linker, base & sugar modifications
Dark quencher
Custom single strand RNA - Guaranteed purity and yield
Rely on first class RNA synthesis up to 80 bases
Custom ssRNA Oligos are delivered in 2ml screw cap tubes according to your specification:
- Hugh variety of RNA modifications
- Purification options: Desalted and HPLC
- Synthesis scales from 0.05 µmol up to 1.0 µmol
- Sequence lengths from 6 to 80 bases
- Quality control by OD measurement and MALDI-TOF MS
- Delivery occurs lyophilised in tube format
Chimeric oligos with RNA, DNA, PTO and 2'O-Methyl-RNA
The use of 2'O-Methyl-RNA in chimeric antisense oligos increases nuclease stability of the oligo.
Chimeric oligonucleotides consist of mixed DNA and RNA bases including methylated bases or phosphorthioate bounds (PTO) in various numbers and compositions.
O-Methyl-RNA / chimerics are delivered in 2ml screw cap tubes according to your specification:
- Hugh variety of RNA modifications
- HPLC purified
- Synthesis scales from 0.05 µmol up to 1.0 µmol
- Sequence lengths from 6 to 80 bases
- Quality control by OD measurement and MALDI-TOF MS
- Delivery occurs lyophilised in tube format
HPLC is required for purification of chimeric oligos. We recommend to perform a Na+ salt exchange with commercially available desalting columns (e.g. NAP or MicroSpin columns) before use in cells or live animals.
Maximum gene silencing with siMAX small interfering RNA
The purpose of siRNAs is to silence several types of RNA
siRNA is a class of double-stranded RNA molecules. It plays an important role in the RNA interference (RNAi) pathway, where it interferes with the expression of specific genes with complementary nucleotide sequence.
We offer custom siRNAs annealed and ready-to-use:
- Desalted and HPLC purified
- Quantity of 20 nmol or 40 nmol
- Guaranteed purity of 85 % (HPLC purified)
- Sequence lengths from 17 - 27 bases
- Quality control by MALDI-TOF MS
A free 1ml 5x siMAX dilution buffer (30 mM HEPES, 100 mM KCl, 1 mM MgCl2, pH = 7.3) is included with each shipment.
CGE: capillary gel electrophoresis
| Fluorescent dyes | 5' | Int | 3' |
|---|---|---|---|
| FAM [FAM] | x | - | - |
| Fluorescein [FLU] | - | - | x |
| Fluorescein-dT [FLUdT] | - | x | - |
| TET [TET] | x | - | - |
| HEX [HEX] | x | - | - |
| Cyanine3 [CY3] | x | - | - |
| TAMRA [TAM] | x | - | x |
| TAMRA-dT [TAMdT] | - | x | - |
| Cyanine5 [CY5] | x | - | - |
| Non fluorescent modifications | 5' | Int | 3' |
|---|---|---|---|
| Amino-C6 [AmC6] | x | - | - |
| Amino-C12 [AmC12] | x | - | - |
| Amino-C3/C6/C7 [AmC3] [AmC6] [AmC7] | - | - | x |
| Biotin [BIO] | x | - | x |
| Biotin-TEG [BIOTEG] | x | - | x |
| Cholesterol [CHOL] | - | - | x |
| Cholesteryl-TEG [CholTEG] | x | - | - |
| Phosphate [PHOS] | x | - | x |
| Spacer, linker, base & sugar modifications | 5' | Int | 3' |
|---|---|---|---|
| 2'-Deoxyinosine [I] | - | x | x |
| 2'-Deoxyuridine [U] | - | x | x |
| 2',3' dideoxyC [23ddC] | - | - | x |
| 5-Methyl-dC [5MedC] | - | x | x |
| Amino-C6-dT [AmC6dT] | - | x | - |
| Biotin-dT [BIOdT] | - | x | - |
| dSpacer [Spd] | - | x | - |
| Spacer C3 [SpC3] | - | x | x |
| Wobble [WOB] (defined ratio) | - | x | - |
| Dark quencher | 5' | Int | 3' |
|---|---|---|---|
| Dabcyl [DAB] | - | - | x |
| Dabcyl-dT [DABdT] | - | x | - |
| Eclipse [Eclip] | - | - | x |
| BHQ1 [BHQ1] | - | - | x |
| BHQ1-dT [BHQ1dT] | - | x | - |
| BHQ2 [BHQ2] | - | - | x |
| BBQ650 [BBQ650] | - | - | x |